Akkermatâ„¢
Fitoactivo que contiene extracto de chile (Capsicum annum), estandarizado en capsaicinoides, encapsulado en una matriz de extracto de fenogreco rica en fibra, galactomanano, que utiliza la tecnologÃa FENUMATâ„¢
What are transdermal dosage forms?
Transdermal dosage forms are dosage forms in which the product is applied to the skin and is diffused through the layers of the skin at a controlled speed, reaching the systemic circulation and being distributed through the tissues until it reaches its site of action. Transdermal dosage forms can be patches, creams, gels, ointments, lotions, gel-creams, plasters and any other pharmaceutical form that allows the active pharmaceutical ingredient (API) to permeate (spread through) the layers of the skin, resulting in a therapeutic effect. The transdermal technology enabled the production of effective systems to promote the absorption of drugs through the skin. The skin covers the surface of the body and represents 16% of the body’s weight. It has a complex structure, being formed by the epidermis (of ectodermal embryonal origin) and dermis (of mesodermal origin), which means that the API needs to cross multiple barriers, in order to gain systemic circulation. Therefore, developing a transdermal dosage form with proven transdermal permeation is a complex task, which can be challenging to the compounding pharmacies worldwide – reason why ready-to-use vehicles like Pentravan® are so important and beneficial.ÂPatient brochure
Pentravan®
Patient brochureThe benefits of transdermal vehicles
The development of transdermal vehicles was stimulated due to the limitations of other conventional drug delivery routes. Transdermal dosage forms offer several benefits over conventional routes, such as avoiding first-pass metabolism, preventing gastrointestinal erosion caused by certain drugs, and offering a sustained release and lower fluctuations of plasma levels. Transdermal vehicles like Pentravan® also have a lower inter- and intrapatient variability, as they are not influenced by gastrointestinal fluids. They are the appropriate choice for APIs with a (very) short half-life, low therapeutic index and/or low oral bioavailability. Medication compounded in transdermal vehicles are also more patient friendly, easier to use, and have better adherence for some medicines, especially when there are prominent oral side-effects. However, some limitations also need to be considered, such as formulations being limited to potent APIs, with low molecular weight (<500 Da), and those that would not irritate or sensitize the skin.
Product brochure
Key facts
Patient friendly with betterÂ
adherence
Most studied transdermalÂ
vehicle for compounding
Permeation studies in endocrinology,Â
aging, and gynecology
Pentravan®
The permeation process for an API involves multiple mechanisms that need to be evaluated for a proper transdermal product. To facilitate transdermal administration and improve safety and efficacy, Fagron has developed Pentravan®, a permeation enhancing vanishing cream that acts as a transdermal delivery system for APIs and is intended for use as a cream base for pharmaceutical compounding. It is ready-to-use to facilitate compounding by the pharmacist. Pentravan® is an oil-in-water emulsion capable to establish a greater rate and extent of absorption of the API than other transdermal bases. Therefore, more of the API will become available in a shorter time to establish the effect of the therapy. Pentravan® is a true vanishing cream, leaving no sticky residue and providing a cosmetically elegant skin feel.- Ready to use vehicle
- Compatible with a wide range of APIs
- Simple compounding process
EPIfactor®
Factor de crecimiento epidérmico biosimilar al factor de crecimiento epidérmico humano (rh-EGF).
Regeneración y reparación biotecnológica de la piel
Los factores de crecimiento son proteÃnas que se comportan como mensajeros quÃmicos e inducen a las células a realizar distintos procesos, incluida la proliferación y diferenciación celular o la apoptosis, entre otros.
Los factores de crecimiento están presentes en prácticamente todas las células del organismo. Existen distintos tipos, cada uno con funciones especÃficas. Si hablamos de EPIfactor®, nos referimos al Factor de Crecimiento Epidérmico (EGF, por sus siglas en inglés), que es el componente principal de este producto.
EPIfactor® actúa como inductor de la regeneración y reparación de la piel. Tiene un papel clave en la cicatrización cutánea, estimulando la proliferación y migración de queratinocitos y fibroblastos, células implicadas en los procedimientos de cicatrización.
Además, su mecansimo de acción le confiere un efecto antiaging, contrarrestando los efectos de la edad y favoreciendo la eliminación de arrugas y la aparición de piel nueva, devolviéndole elasticidad y firmeza.
Literatura del producto
Datos clave
60 dÃas
de estabilidad del producto formulado
Absoluta
biocompatibilidad
Compatible
con diferentes bases de Fagron Advanced Derma
EPIfactor®
EPIfactor® se ha formulado en un vehÃculo oleoso, optimizando su estabilidad para que sea funcional el máximo tiempo posible.
En viales de 1ml, se incorpora directamente a una de las bases compatibles, con la posibilidad de añadir otros activos para completar la formulación (por ejemplo, hialuronato de sodio, aceite de rosa mosqueta, eritromicina, etc.).
¡Incorpora EPIfactor® a todas aquellas formulaciones que necesiten bioestimulación, regeneración tisular o cicatrización!